Description

Indoleamine-2,3-Dioxygenase Inhibitor Incb024360 is a potent and selective small molecule inhibitor of the IDO1 enzyme, a key regulator of immune tolerance in the tumor microenvironment. This compound matters for its critical role in preclinical and clinical research focused on immuno-oncology and developing novel cancer immunotherapies. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions engaged in studying immune checkpoint pathways and developing therapeutic agents to enhance anti-tumor immune responses.

Application

• Immuno-oncology Research: A key tool compound for investigating the role of the IDO pathway in tumor immune evasion and for validating IDO1 as a therapeutic target.
• Preclinical Drug Development: Used in in vitro and in vivo studies to assess the efficacy of IDO inhibition in combination with other therapies, such as checkpoint inhibitors, chemotherapy, or radiotherapy.
• Mechanistic Studies: Essential for elucidating the biochemical and cellular mechanisms of tryptophan metabolism and its impact on T-cell function and proliferation.
• Biomarker Research: Supports studies aimed at identifying patient populations most likely to respond to IDO-targeted therapies.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in assay development and screening campaigns for novel IDO inhibitors.
• Inflammatory & Autoimmune Disease Research: Applied in research models exploring the role of IDO in conditions beyond cancer, including autoimmune disorders and chronic inflammation.

Basic Information

Product Name	Indoleamine-2,3-Dioxygenase Inhibitor Incb024360
CAS No.	914471-09-3
Molecular Formula	C₂₀H₁₉N₅O₂
Molecular Weight	361.40 g/mol
Synonyms	INCB024360; INCB 024360; INCB-024360; (1R,3r,5S)-8-((1H-Pyrazol-4-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxamide; 8-[(1H-Pyrazol-4-yl)methyl]-8-azabicyclo[3.2.1]octane-3-carboxamide; Epacadostat; IDO1 Inhibitor INCB024360
EINECS	Contact for details

Quality Control

Our INCB024360 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, analytical methods, and results is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.