Description

Cazpaullone CAS NO 914088-64-5 is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3), a key enzyme implicated in various cellular signaling pathways. This compound is a critical research tool for studying the role of GSK-3 in biological processes such as cell proliferation, differentiation, and metabolism. It is primarily utilized by researchers and scientists in the fields of pharmaceutical development, biochemistry, and molecular biology for target validation and pathway analysis.

Application

• Biomedical Research: Used as a selective GSK-3β inhibitor to study Wnt/β-catenin signaling pathways, neuronal development, and cell cycle regulation.
• Drug Discovery: Serves as a key pharmacological tool for target validation in therapeutic areas including neurodegenerative diseases (e.g., Alzheimer's), diabetes, and cancer.
• Cell Biology Studies: Applied in *in vitro* assays to investigate the effects of GSK-3 inhibition on stem cell differentiation, apoptosis, and glycogen metabolism.
• Academic Research: A standard reagent in university and institutional labs for fundamental research into kinase biology and signal transduction mechanisms.
• High-Throughput Screening (HTS): Can be used as a reference compound in assay development and screening campaigns to identify novel GSK-3 modulators.

Basic Information

Product Name	Cazpaullone
CAS No.	914088-64-5
Molecular Formula	C₁₆H₁₀N₂O₂
Molecular Weight	262.26 g/mol
Synonyms	9-Cyano-1-azapaullone; Cazpaullone; GSK-3 Inhibitor IX; 9-Cyano-1-azapaullone; 6-Cyano-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; 1-Azakenpaullone; CAS 914088-64-5
EINECS	Contact for details

Quality Control

Our Cazpaullone is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality systems are designed to meet the rigorous demands of the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.