Description

Cl-Amidine is a potent and selective covalent inhibitor of protein arginine deiminases (PADs), a class of enzymes implicated in various pathological conditions. This high-purity chemical building block is essential for researchers and developers in the life sciences sector, enabling the study of citrullination pathways and the development of novel therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on autoimmune diseases, cancer, and neurodegenerative disorders.

Application

• Pharmaceutical Research & Development: Serves as a key chemical probe and building block for developing novel PAD inhibitors targeting conditions like rheumatoid arthritis, multiple sclerosis, and lupus.
• Biochemical Assay Development: Used as a standard and active compound in high-throughput screening (HTS) and enzyme activity assays to study PAD enzyme kinetics and inhibition.
• Epigenetics and Cancer Research: Employed to investigate the role of protein citrullination in gene regulation, neutrophil extracellular trap (NET) formation, and cancer progression.
• Inflammatory Disease Models: Applied in in vitro and in vivo studies to validate PADs as therapeutic targets for inflammatory and autoimmune diseases.
• Chemical Biology Tool: Utilized for activity-based protein profiling (ABPP) to identify and characterize PAD enzyme activity in complex biological systems.
• Process Chemistry & Scale-up: Acts as a critical intermediate for the GMP-scale synthesis of clinical candidate molecules for preclinical and clinical trials.

Basic Information

Product Name	Cl-Amidine
CAS No.	913723-61-2
Molecular Formula	C8H16ClN5O2
Molecular Weight	249.70 g/mol
Synonyms	N-α-Benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide; (2S)-5-(Aminoiminomethyl)amino-2-benzamido-N-(2-chloroethylidene)pentanamide; 2-Chloroacetamidine; PAD Inhibitor Cl-Amidine; Benzoyl-Orn(Caa)-NH2; L-Ornithine, N2-benzoyl-N5-[(2-chloro-1-iminoethyl)amino]-, amide; Protein Arginine Deiminase Inhibitor
EINECS	Contact for details

Quality Control

Our Cl-Amidine (CAS 913723-61-2) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.