Description

2-Chloro-5-Fluoropyridine-3-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl and heterobiaryl structures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules. Its specific substitution pattern offers precise control over molecular architecture in target-oriented synthesis.

Application

• Pharmaceutical Intermediate: Critical for synthesizing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of new generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Biology & Probe Design: Utilized for labeling and modifying biomolecules or creating chemical probes for biological target identification.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	2-Chloro-5-Fluoropyridine-3-Boronic Acid
CAS No.	913373-43-0
Molecular Formula	C5H4BClFNO2
Molecular Weight	175.36 g/mol
Synonyms	(2-Chloro-5-fluoropyridin-3-yl)boronic acid; 3-Borono-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-3-pyridineboronic acid; 5-Fluoro-2-chloropyridine-3-boronic acid; 913373-43-0; 2-Chloro-5-fluoropyridine-3-boronic acid pinacol ester (common derivative); 2-Chloro-5-fluoro-3-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyridine-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.