Description

Vincaleukoblastin-?23-?Oic Acid, O4-?Deacetyl-?, 2-?[[2-?(2-?Pyridinyldithio)?Ethoxy]?Carbonyl]?Hydrazide is a sophisticated chemical intermediate designed for advanced bioconjugation and targeted drug delivery applications. Its core value lies in its functionalized structure, which enables the precise attachment of therapeutic payloads to antibodies or other targeting molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation antibody-drug conjugates (ADCs) and other targeted therapies.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a critical intermediate for constructing cleavable linkers that connect cytotoxic agents to monoclonal antibodies.
• Bioconjugation Reagent: Used to functionalize proteins, peptides, and other biomolecules with pyridyldithiol groups for subsequent thiol-based coupling reactions.
• Targeted Cancer Therapy Development: A key building block in the research and production of novel chemotherapeutic agents designed to minimize off-target effects.
• Prodrug Synthesis: Employed in the creation of prodrugs where the active pharmaceutical ingredient is released upon specific biological triggers.
• Diagnostic Agent Conjugation: Facilitates the attachment of imaging agents or dyes to targeting vectors for diagnostic applications.
• Polymer-Drug Conjugate Research: Used in the development of advanced polymer-based drug delivery systems for controlled release.

Basic Information

Product Name	Vincaleukoblastin-?23-?Oic Acid, O4-?Deacetyl-?, 2-?[[2-?(2-?Pyridinyldithio)?Ethoxy]?Carbonyl]?Hydrazide
CAS No.	913082-13-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	O4-Deacetyl-2-[[2-(2-pyridinyldithio)ethoxy]carbonyl]hydrazide of Vincaleukoblastin-23-oic Acid; Vincaleukoblastin-23-oic Acid, O4-Deacetyl-, 2-[[2-(2-Pyridinyldithio)ethoxy]carbonyl]hydrazide; ADC Linker-Payload Intermediate; Vinca Alkaloid-Pyridyldithiol Conjugate; SPDP-Derived Vinca Alkaloid; N-Succinimidyl 3-(2-pyridyldithio)propionate-Vinca Conjugate Precursor; Targeted Drug Delivery Intermediate
EINECS	Contact for details

Quality Control

Our Vincaleukoblastin derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of ADC and bioconjugation applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.