Description

1-[Tris(Propan-2-Yl)Silyl]-1H-Indole-6-Sulfonyl Chloride is a specialized organosilicon reagent featuring a sulfonyl chloride functional group, making it a valuable building block for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for the development of complex molecules. It is primarily utilized in pharmaceutical research, agrochemical development, and materials science for constructing novel indole-based architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the indole scaffold for bioactivity.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic materials where the silyl group aids in solubility and processability.
• Chemical Biology Probes: Acts as a reagent for labeling and modifying biomolecules due to the reactivity of the sulfonyl chloride group with amines and alcohols.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1-[Tris(Propan-2-Yl)Silyl]-1H-Indole-6-Sulfonyl Chloride
CAS No.	912846-33-4
Molecular Formula	C19H30ClNO2SSi
Molecular Weight	399.04 g/mol
Synonyms	1-[Tris(isopropyl)silyl]-1H-indole-6-sulfonyl chloride; 1-Triisopropylsilyl-1H-indole-6-sulfonyl chloride; 1H-Indole-6-sulfonyl chloride, 1-[tris(1-methylethyl)silyl]-; 1-(Triisopropylsilyl)indole-6-sulfonyl chloride; TIPS-indole-6-sulfonyl chloride; 1-TIPS-1H-indole-6-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-[Tris(Propan-2-Yl)Silyl]-1H-Indole-6-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.