Description

N2'-Deacetyl-N2'-[3-(Methylthio)-1-Oxopropyl]-Maytansine is a potent maytansinoid derivative, a class of compounds renowned for their exceptional cytotoxicity. This compound serves as a critical intermediate and payload in the development of Antibody-Drug Conjugates (ADCs), a revolutionary class of targeted cancer therapeutics. It is essential for pharmaceutical R&D teams, process chemists, and manufacturers focused on oncology drug discovery and bioconjugation technology.

Application

• Antibody-Drug Conjugate (ADC) Payload: As a cytotoxic warhead, it is chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Drug Discovery: A key intermediate in the synthesis and research of novel maytansinoid-based chemotherapeutic agents.
• Bioconjugation Research: Used in studies to develop new linker technologies and optimize drug-antibody ratio (DAR) for ADC efficacy and stability.
• Mechanistic Studies: Employed in biochemical research to investigate tubulin inhibition and apoptosis induction mechanisms.
• Process Development: Serves as a reference standard and starting material for scaling up ADC payload synthesis under cGMP conditions.

Basic Information

Product Name	N2'-Deacetyl-N2'-[3-(Methylthio)-1-Oxopropyl]-Maytansine
CAS No.	912569-84-7
Molecular Formula	C36H48ClN3O9S
Molecular Weight	734.30 g/mol
Synonyms	DM1-SMe; Maytansinoid DM1 methyl disulfide derivative; N2'-Deacetyl-N2'-(3-methylthio-1-oxopropyl)maytansine; Ansamitocin P-3 derivative; DM1 precursor; mertansine intermediate; Tubulin inhibitor DM1 analog; NSC 366140 analog
EINECS	Contact for details

Quality Control

Our N2'-Deacetyl-N2'-[3-(Methylthio)-1-Oxopropyl]-Maytansine is manufactured and controlled to meet the stringent requirements for pharmaceutical intermediates. We adhere to a robust quality management system, with batch-specific testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity and related substance profiles, are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.