Description

4-Pyrimidin-2-Ylbenzenesulphonyl Chloride is a high-purity sulfonyl chloride derivative, a key reactive intermediate in modern organic synthesis. Its primary value lies in its role as a versatile building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable and high-quality source for advanced synthetic transformations.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the pyrimidine and sulfonamide motifs are common.
• Chemical Research & Development: Serves as a versatile reagent for introducing the sulfonyl functional group in medicinal chemistry and material science research.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scalable production of APIs that contain sulfonamide or sulfonylurea pharmacophores.
• Ligand and Catalyst Development: Useful for creating specialized ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Pyrimidin-2-Ylbenzenesulphonyl Chloride
CAS No.	912569-53-0
Molecular Formula	C10H7ClN2O2S
Molecular Weight	254.69 g/mol
Synonyms	2-(4-Chlorosulfonylphenyl)pyrimidine; 4-(Pyrimidin-2-yl)benzenesulfonyl chloride; 2-(4-Chlorosulfonylphenyl)pyrimidine; Benzenesulfonyl chloride, 4-(2-pyrimidinyl)-; 4-(2-Pyrimidyl)benzenesulfonyl chloride; 2-(4-Chlorosulphonylphenyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Pyrimidin-2-Ylbenzenesulphonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.