Description

Chk1-In-2 CAS NO 912367-45-4 is a potent and selective small molecule inhibitor of the Checkpoint kinase 1 (Chk1) protein. This compound is critical for disrupting specific DNA damage response pathways in cells, making it a valuable tool for targeted biological research. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on oncology, cell cycle regulation, and the development of novel chemotherapeutic adjuvants.

Application

• Biochemical Research: Used as a selective probe to study the role of Chk1 kinase in cell cycle checkpoints and DNA damage response mechanisms.
• Oncology Drug Discovery: Serves as a key reference compound and pharmacological tool in screening assays and preclinical studies for cancer therapeutics.
• Cell Biology Studies: Employed to investigate sensitization of cancer cells to DNA-damaging agents, exploring combination therapy strategies.
• Mechanism of Action (MoA) Analysis: Essential for validating drug targets and understanding signaling pathways involved in genome integrity.
• High-Throughput Screening (HTS): Utilized as a control or standard in automated screening platforms to identify new Chk1 modulators.

Basic Information

Product Name	Chk1-In-2
CAS No.	912367-45-4
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Chk1 Inhibitor 2; 6-Cyclohexylmethoxy-5-(3-morpholin-4-ylpropoxy)pyrimidine-2,4-diamine; 6-[(Cyclohexylmethoxy)methyl]-5-[(3-morpholin-4-ylpropoxy)methyl]pyrimidine-2,4-diamine; Chk1 Inhibitor II; CHK1-IN-2; CAS 912367-45-4
EINECS	Contact for details

Quality Control

Every batch of Chk1-In-2 is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.