Description

17-AAG (Hydrochloride) is a potent and selective inhibitor of the Hsp90 molecular chaperone, a key target in oncology research. This compound is critical for studying protein folding, cellular stress response pathways, and the degradation of client oncoproteins. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on cancer therapeutics and molecular biology.

Application

• Oncology Research: Used as a key pharmacological tool to study Hsp90 inhibition and its effects on cancer cell proliferation and survival.
• Molecular Biology Studies: Employed in investigating protein degradation pathways, chaperone function, and cellular stress responses.
• Preclinical Drug Development: Serves as a reference compound and lead molecule in the development of novel Hsp90-targeted anti-cancer agents.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro assays to evaluate Hsp90 inhibitor potency and specificity.
• Signal Transduction Research: Applied to study the role of Hsp90 client proteins (e.g., HER2, AKT, RAF) in various oncogenic signaling cascades.

Basic Information

Product Name	17-AAG (Hydrochloride)
CAS No.	911710-03-7
Molecular Formula	C31H44N4O8 • HCl
Molecular Weight	645.16 g/mol (as hydrochloride salt)
Synonyms	17-Allylamino-17-demethoxygeldanamycin Hydrochloride; Tanespimycin Hydrochloride; 17-DMAG Hydrochloride; 17-AAG HCl; NSC 330507; Benzoquinone ansamycin 17-AAG HCl; CP 127374
EINECS	Contact for details

Quality Control

Our 17-AAG (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.