Description

5,5-Difluoro-2-Oxo-Piperidin-1-Carboxylic Acid T-Butyl Ester is a high-purity, protected piperidinone derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique difluorinated oxopiperidine scaffold, which is essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly protease inhibitors and other enzyme-targeted therapeutics.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the difluoro group can enhance bioavailability and stability.
• Chemical Biology Probe Synthesis: Employed to create labeled or tagged molecules for studying biological pathways and target engagement.
• Peptidomimetic Chemistry: Serves as a constrained, fluorinated scaffold to mimic peptide backbones, improving metabolic stability.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or ligands with unique electronic properties.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploratory synthesis projects.

Basic Information

Product Name	5,5-Difluoro-2-Oxo-Piperidin-1-Carboxylic Acid T-Butyl Ester
CAS No.	911634-76-9
Molecular Formula	C11H15F2NO3
Molecular Weight	247.24 g/mol
Synonyms	1-Boc-5,5-difluoropiperidin-2-one; tert-Butyl 5,5-difluoro-2-oxopiperidine-1-carboxylate; 5,5-Difluoro-2-oxo-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-5,5-difluoropiperidin-2-one; 5,5-Difluoro-1-N-Boc-piperidin-2-one; N-Boc-5,5-difluoro-2-piperidinone; Boc-5,5-difluoro-2-piperidone
EINECS	Contact for details

Quality Control

Our 5,5-Difluoro-2-Oxo-Piperidin-1-Carboxylic Acid T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.