Description

(3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-Dihydroxy-3-(Methyl- 13 C)-1H-2-Benzoxacyclotetradecin-1,7(8H)-Dione- 13 C 17 is a high-purity, carbon-13 labeled macrolide compound, serving as a critical stable isotope-labeled standard for advanced analytical research. Its primary value lies in enabling precise quantification and metabolic pathway tracing in complex biological matrices, ensuring data accuracy and reliability. This product is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical sectors, particularly those involved in drug metabolism and pharmacokinetics (DMPK) studies, environmental analysis, and the development of novel therapeutic agents.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis to ensure accurate measurement of target analytes.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for tracing the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds in preclinical and clinical research.
• Metabolomics and Proteomics Research: Enables precise tracking of biochemical pathways and protein interactions in complex biological systems.
• Environmental Fate Studies: Applied to monitor the degradation, transformation, and bioaccumulation of chemical substances in environmental samples.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradants during drug development.
• Clinical Diagnostics Development: Serves as a calibrant in the development of highly sensitive diagnostic assays for disease biomarkers.
• Agrochemical Research: Used in studies investigating the metabolism and residue analysis of pesticides and herbicides.
• Isotope Dilution Analysis (IDA): A fundamental component of IDA methodologies for achieving the highest possible analytical accuracy.

Basic Information

Product Name	(3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-Dihydroxy-3-(Methyl- 13 C)-1H-2-Benzoxacyclotetradecin-1,7(8H)-Dione- 13 C 17
CAS No.	911392-43-3
Molecular Formula	C₁₇H₂₂O₆ (with 13C label at specified position)
Molecular Weight	~322.36 g/mol (exact mass varies with isotope enrichment)
Synonyms	13C-Labeled Macrolide Standard; 13C-Methyl Brefeldin A Analog; Isotopically Labeled Benzoxacyclotetradecin Dione; (3S,11E)-14,16-Dihydroxy-3-(13C-methyl)macrolide; Stable Isotope-Labeled Internal Standard (IS); Carbon-13 Labeled Polyketide; CAS 911392-43-3; 13C-Brefeldin A Related Compound
EINECS	Contact for details

Quality Control

Every batch of our carbon-13 labeled standard is produced and tested under strict quality management protocols to ensure exceptional isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). Our quality system is designed to meet the rigorous demands of analytical research and complies with relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C (at specified position)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.