Description

Decanoyl-Arg-Arg-Leu-Leu-Chloromethylketone is a potent and selective synthetic peptide chloromethylketone inhibitor designed for targeted protease research. This compound matters for its high-affinity binding and irreversible inhibition, providing researchers with a critical tool for mechanistic studies and pathway validation. It is primarily needed by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) focused on enzymology, oncology, and inflammatory disease target discovery.

Application

• Protease Inhibition Studies: Used as a specific, irreversible inhibitor to study the function and mechanism of target proteases in biochemical assays.
• Drug Discovery & Target Validation: Serves as a key pharmacological tool in hit validation and lead optimization for therapeutic programs targeting proteolytic enzymes.
• Enzymology Research: Employed in kinetic studies to determine enzyme activity, inhibition constants (Ki), and catalytic mechanisms.
• Cell Signaling Pathway Analysis: Utilized to dissect and modulate specific protease-dependent signaling cascades in cellular models.
• Biomarker Research: Acts as a reference compound in the development of activity-based probes (ABPs) for detecting active proteases in complex samples.
• High-Throughput Screening (HTS): Functions as a control compound in screening campaigns to identify novel protease inhibitors.

Basic Information

Product Name	Decanoyl-Arg-Arg-Leu-Leu-Chloromethylketone
CAS No.	911379-57-2
Molecular Formula	C39H74ClN11O7
Molecular Weight	852.52 g/mol
Synonyms	Decanoyl-RRLL-CMK; Dec-RRLL-CMK; (2S)-1-[(2S)-6-[(2S)-5-[(2S)-2-[[(2S)-5-[(diaminomethylidene)amino]-1-[(2S)-1-[(2S)-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl]amino]-1-oxo-4-(propan-2-yl)butan-2-yl]amino]-1-oxo-4-(propan-2-yl)butan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-chloro-1-oxobutan-2-yl] decanoate; Peptide Chloromethyl Ketone Inhibitor; Protease Inhibitor RRLL-CMK
EINECS	Contact for details

Quality Control

Our Decanoyl-Arg-Arg-Leu-Leu-Chloromethylketone is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and related substances are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Assay	≥97.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.