Description

A-83-01 is a potent and selective small molecule inhibitor targeting the TGF-β type I receptor ALK5, as well as ALK4 and ALK7. This compound is crucial for researchers and developers in the life sciences sector, as it effectively blocks TGF-β/Activin/Nodal signaling pathways, which are central to numerous cellular processes. It is an essential tool for high-value applications in pharmaceutical R&D, particularly in the study of cancer biology, fibrosis, stem cell differentiation, and metabolic disorders. The product, identified by CAS NO 909910-43-6, is supplied to meet the stringent demands of global biotechnology and academic research institutions.

Application

• Biomedical Research: A key reagent for investigating the role of TGF-β signaling in cancer progression, epithelial-mesenchymal transition (EMT), and metastasis.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and lead optimization for therapies targeting fibrosis and oncology.
• Stem Cell Research: Facilitates the maintenance of pluripotency in embryonic stem cells and directs differentiation protocols by modulating SMAD2/3 signaling.
• Academic & Institutional Labs: Employed in foundational studies of cell signaling, developmental biology, and molecular pharmacology.
• Biochemical Assay Development: Serves as a critical control compound in kinase inhibition assays and pathway analysis kits.

Basic Information

Product Name	A-83-01
CAS No.	909910-43-6
Molecular Formula	C₂₅H₁₉N₅O₃
Molecular Weight	437.45 g/mol
Synonyms	3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; ALK5 Inhibitor II; TGF-β RI Kinase Inhibitor IV; 6-Methyl-2-pyridinyl-N-phenyl-4-quinolin-4-yl-1H-pyrazole-1-carbothioamide; A83-01; A 83-01
EINECS	Contact for details

Quality Control

Every batch of A-83-01 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and potency. Our standard grade meets the high-purity requirements for research use, with specifications verified by advanced techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.