Description

Eg5 Inhibitor IV, VS-83 is a potent and selective small molecule inhibitor of the kinesin spindle protein Eg5, a critical target in oncology research. This compound is valued for its high specificity and efficacy in disrupting mitotic spindle formation, leading to cell cycle arrest and apoptosis in proliferating cells. It is an essential research tool for scientists in pharmaceutical R&D and academic institutions focused on cancer biology, anti-mitotic drug discovery, and preclinical studies.

Application

• Cancer Research & Drug Discovery: A key pharmacological tool for studying mitotic mechanisms and validating Eg5 as a therapeutic target in various cancer cell lines.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate the efficacy and pharmacokinetics of anti-mitotic agents.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize novel Eg5 inhibitors.
• Mechanistic Studies: Enables research into spindle assembly checkpoint function, aneuploidy, and mechanisms of drug resistance in oncology.
• Academic Research: Supports fundamental cell biology research in universities and research institutes exploring cell division and mitosis.

Basic Information

Product Name	Eg5 Inhibitor IV, VS-83
CAS No.	909250-29-9
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	VS-83; Eg5 Inhibitor IV; 5-(3-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-2-methoxybenzonitrile; Monastrol derivative; Kinesin Spindle Protein (KSP) Inhibitor; KIF11 Inhibitor; (+)-Monastrol analog
EINECS	Contact for details

Quality Control

Our Eg5 Inhibitor IV, VS-83 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, NMR and mass spectrometry for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.