Description

4-Bromo-2-Chloro-3-Fluorotoluene is a high-purity halogenated toluene derivative, serving as a critical building block in advanced organic synthesis. Its precise substitution pattern makes it an indispensable intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the fluorine and halogen atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Material Research: Intermediate for creating specialty polymers, ligands for catalysis, and advanced organic frameworks with tailored electronic properties.
• Cross-Coupling Reactions: Valuable substrate in Suzuki, Stille, and Negishi cross-coupling reactions to construct complex biaryl systems.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Bromo-2-Chloro-3-Fluorotoluene
CAS No.	909122-21-0
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-Bromo-4-chloro-2-fluoro-5-methylbenzene; 2-Chloro-3-fluoro-4-bromotoluene; 4-Bromo-2-chloro-3-fluoro-1-methylbenzene; Toluene, 4-bromo-2-chloro-3-fluoro-; 5-Methyl-2-chloro-3-fluorobromobenzene; 2-Chloro-4-bromo-3-fluorotoluene; 3-Fluoro-4-bromo-2-chlorotoluene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-3-Fluorotoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with global regulatory frameworks, including REACH and TSCA.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.