Description

4-Fluoro-5-Isoquinolinesulfonyl Chloride Hydrochloride (1:1) is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters for its role as a key building block in the development of novel pharmaceutical agents and bioactive molecules, particularly in medicinal chemistry research. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic structures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Probe Development: Serves as a starting material for creating sulfonamide-based probes and enzyme inhibitors for biological studies.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients for crop protection products.
• Specialty Chemical Manufacturing: Utilized in the production of advanced materials, dyes, and other high-value fine chemicals.

Basic Information

Item	Details
Product Name	4-Fluoro-5-Isoquinolinesulfonyl Chloride Hydrochloride (1:1)
CAS No.	906820-08-4
Molecular Formula	C9H5ClFNO2S · HCl
Molecular Weight	282.52 g/mol (Free base: 245.66 g/mol)
Synonyms	5-Isoquinolinesulfonyl chloride, 4-fluoro-, hydrochloride (1:1); 4-Fluoro-5-isoquinolinesulfonyl chloride HCl; 4-Fluoro-5-isoquinolinesulphonyl chloride hydrochloride; 4-Fluoro-isoquinoline-5-sulfonyl chloride hydrochloride; 906820-08-4; 4-Fluoro-5-isoquinolinesulfonyl chloride monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-5-Isoquinolinesulfonyl Chloride Hydrochloride (1:1) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.