Description

Pyruvic Acid-13C Ethyl Ester is a stable isotope-labeled derivative of pyruvic acid, a key intermediate in cellular metabolism. This compound is essential for advanced research and development, providing a critical tool for metabolic pathway tracing and quantitative analysis using mass spectrometry. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for drug discovery, metabolic studies, and the synthesis of labeled active pharmaceutical ingredients (APIs).

Application

• Metabolic Flux Analysis (MFA): Used as a 13C-labeled tracer to study central carbon metabolism in cells, tissues, or microorganisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard for the accurate quantification of pyruvate and related metabolites in bioanalytical assays.
• Synthesis of Labeled Compounds: A key building block for the preparation of more complex 13C-labeled molecules for research and diagnostic applications.
• Biochemical Research: Employed in enzymatic studies and investigations of metabolic disorders to elucidate biochemical pathways.
• Pharmaceutical Development: Used in the development and validation of analytical methods for new drug candidates that interact with metabolic pathways.
• Nutritional Science: Applied in research studying energy metabolism, exercise physiology, and the effects of nutrients.

Basic Information

Product Name	Pyruvic Acid-13C Ethyl Ester
CAS No.	905440-74-6
Molecular Formula	C5H813CO3 or C4H8O2*13C
Molecular Weight	119.12 g/mol (for 13C1)
Synonyms	Ethyl Pyruvate-1-13C; Ethyl 2-Oxopropanoate-1-13C; 1-13C-Ethyl Pyruvate; Ethyl (1-13C)pyruvate; Pyruvic-1-13C Acid Ethyl Ester; Ethyl 2-Oxo(1-13C)propionate; Ethyl α-Ketopropionate-1-13C
EINECS	Contact for details

Quality Control

Our Pyruvic Acid-13C Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, GC-MS, and HPLC, to ensure high chemical and isotopic purity. Certificates of Analysis (COA) detailing batch-specific results for identity, assay, isotopic enrichment, and purity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its highly volatile nature, keep the container tightly sealed when not in use. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.