Description

Limk1 Inhibitor Bms 4 is a potent and selective small molecule inhibitor targeting the LIM domain kinase 1 (LIMK1) pathway. This compound is a critical research tool for investigating cytoskeletal dynamics, cell motility, and related disease mechanisms, offering high specificity and reliable biological activity. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurology, and fibrosis research programs.

Application

• Biomedical Research: A key reagent for studying actin polymerization, cofilin phosphorylation, and the role of the Rho/ROCK/LIMK pathway in cellular processes.
• Oncology Research: Investigated for its potential to inhibit cancer cell invasion, metastasis, and tumor progression by disrupting the cytoskeletal machinery.
• Neurological Disease Models: Used in research models for Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions where LIMK1 activity is implicated.
• Cardiovascular Research: Applied in studies exploring vascular remodeling, hypertension, and pulmonary arterial hypertension (PAH).
• Fibrosis Research: Evaluated for anti-fibrotic effects in models of renal, hepatic, and pulmonary fibrosis.
• Preclinical Development: Serves as a lead compound or pharmacological probe for validating LIMK1 as a therapeutic target in various disease areas.

Basic Information

Product Name	Limk1 Inhibitor Bms 4
CAS No.	905298-84-2
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	BMS-4; BMS 4; BMS4; LIMK1 Inhibitor BMS-4; 3-[(3S,4R)-3-[(3,4-Difluorophenyl)methoxy]-1-(2-hydroxy-2-methylpropyl)-4-piperidinyl]-1H-indole-5-carbonitrile; (3S,4R)-3-((3,4-Difluorobenzyl)oxy)-1-(2-hydroxy-2-methylpropyl)-4-(5-cyano-1H-indol-3-yl)piperidine
EINECS	Contact for details

Quality Control

Our Limk1 Inhibitor Bms 4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage, consider storing under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.