Description

GDC-0879 is a potent and selective small molecule inhibitor of the B-Raf kinase, specifically targeting the V600E mutant form. This compound is a critical research tool for investigating the MAPK/ERK signaling pathway, which is implicated in various cellular processes including proliferation and survival. It is primarily utilized by researchers and pharmaceutical developers in the fields of oncology, molecular biology, and preclinical drug discovery for target validation and mechanistic studies. The product is supplied under the identifier CAS No. 905281-76-7.

Application

• Biochemical Research: Used as a selective probe to study the role of B-Raf V600E in the MAPK/ERK signaling cascade and its downstream effects.
• Oncology Research: Serves as a key compound in in vitro and cellular assays to investigate tumorigenesis driven by B-Raf mutations and to evaluate potential therapeutic strategies.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and hit-to-lead optimization campaigns for developing novel oncology therapeutics.
• Cell Signaling Studies: Facilitates the exploration of kinase inhibitor specificity and the functional consequences of pathway inhibition in various cell lines.
• Preclinical Modeling: Used in the development and validation of animal models for cancers harboring B-Raf mutations to assess efficacy and mechanism of action.

Basic Information

Product Name	GDC-0879
CAS No.	905281-76-7
Molecular Formula	C₁₈H₂₁N₅O₂
Molecular Weight	339.39 g/mol
Synonyms	GDC0879; GDC 0879; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1S)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; B-Raf V600E inhibitor; BRAF inhibitor GDC-0879; (S)-GDC-0879
EINECS	Contact for details

Quality Control

Our GDC-0879 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity, water content, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.