Description

Benzene, 1-Fluoro-2-Iodo-4,5-Dimethyl- is a highly functionalized halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on a dimethylbenzene core, makes it a versatile precursor for constructing complex molecules via cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly for introducing halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the specific halogen pattern influences bioactivity.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in transition metal catalysis.
• Organic Electronic Materials: Employed in the synthesis of functionalized arenes for potential use in OLEDs or semiconductor materials.
• Cross-Coupling Reactions: The iodine moiety is an excellent handle for Suzuki, Stille, and other palladium-catalyzed coupling reactions to form biaryl structures.
• Fluorine Chemistry Research: Provides a platform for studying the influence of fluorine atoms on the reactivity and physical properties of aromatic systems.

Basic Information

Product Name	Benzene, 1-Fluoro-2-Iodo-4,5-Dimethyl-
CAS No.	905275-28-7
Molecular Formula	C8H8FI
Molecular Weight	250.05 g/mol
Synonyms	1-Fluoro-2-iodo-4,5-dimethylbenzene; 4,5-Dimethyl-1-fluoro-2-iodobenzene; 2-Fluoro-1-iodo-4,5-dimethylbenzene; 1-Fluoro-2-iodo-4,5-dimethyl-benzene; 4,5-Dimethyl-2-fluoroiodobenzene; 905275-28-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our Benzene, 1-Fluoro-2-Iodo-4,5-Dimethyl- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization including HPLC for purity assessment, NMR (1H, 13C, 19F) for structural confirmation, and GC-MS to identify and quantify volatile impurities. Certificates of Analysis (COA) with detailed specifications are provided to ensure traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry and inert atmosphere when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.