Description

2-Methoxy-4-(Trifluoromethoxy)Phenylsulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, enabling the introduction of both the sulfonyl moiety and the unique 2-methoxy-4-(trifluoromethoxy)phenyl scaffold into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with potential enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides that leverage the trifluoromethoxy group for improved bioactivity and metabolic stability.
• Material Science Research: Used in the creation of specialized monomers or polymers for advanced materials with specific surface or electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise chemical architecture.

Basic Information

Product Name	2-Methoxy-4-(Trifluoromethoxy)Phenylsulfonyl Chloride
CAS No.	905077-08-9
Molecular Formula	C9H6ClF3O4S
Molecular Weight	302.65 g/mol
Synonyms	1-Methoxy-2-(Trifluoromethoxy)-4-(Chlorosulfonyl)Benzene; 4-Methoxy-3-(Trifluoromethoxy)Benzenesulfonyl Chloride; 2-Methoxy-α,α,α-trifluoro-p-toluenesulfonyl Chloride (related analog); 4-(Trifluoromethoxy)-2-Methoxybenzenesulfonyl Chloride; 2-Methoxy-4-Trifluoromethoxybenzenesulfonyl Chloride; 4-Methoxy-3-trifluoromethoxybenzenesulfonyl chloride; 905077-08-9 (CAS Index Name); Aryl Sulfonyl Chloride Intermediate
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxy-4-(Trifluoromethoxy)Phenylsulfonyl Chloride is produced and tested under a strict quality management system. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0 - 102.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.