Description

trans-Latanoprost Acid CAS NO 903549-49-5 is a high-purity, synthetic prostaglandin F2α analog intermediate. This compound is of critical importance in the pharmaceutical industry for the synthesis of advanced ophthalmic medications. It is primarily required by manufacturers of active pharmaceutical ingredients (APIs) and research institutions developing treatments for glaucoma and ocular hypertension.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral intermediate in the commercial production of Latanoprost and related prostaglandin analog ophthalmic solutions.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for developing novel intraocular pressure-lowering drugs.
• Process Chemistry & Scale-Up: Serves as a critical building block for process optimization and manufacturing route development in GMP environments.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Chemical Synthesis: Utilized in organic synthesis for creating novel prostaglandin derivatives with potential therapeutic applications.

Basic Information

Product Name	trans-Latanoprost Acid
CAS No.	903549-49-5
Molecular Formula	C26H40O5
Molecular Weight	432.60 g/mol
Synonyms	trans-Latanoprost Free Acid; (5Z,13E,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinorprosta-5,13-dien-1-oic Acid; Latanoprost Impurity F (trans-isomer); Latanoprost Related Compound F; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-, (5Z,13E,15R)-; UNII-9KX1C8S5A6; Latanoprost EP Impurity F; Latanoprost Acid trans-Isomer
EINECS	Contact for details

Quality Control

Our trans-Latanoprost Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee traceability and compliance with customer specifications and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store unopened vials at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.