Description

3-Fluoropyridine-2-Thialdehyde is a high-value, multifunctional heterocyclic building block characterized by its reactive aldehyde and thioaldehyde groups on a fluorinated pyridine scaffold. This compound matters for its unique electronic properties and versatility in facilitating complex molecular transformations, enabling the synthesis of novel pharmacophores and advanced materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry, ligand synthesis, and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile building block for creating complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and functional polymers due to its electron-deficient pyridine core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a fluorinated heterocyclic aldehyde moiety.

Basic Information

Product Name	3-Fluoropyridine-2-Thialdehyde
CAS No.	902518-40-5
Molecular Formula	C6H4FNS
Molecular Weight	141.17 g/mol
Synonyms	2-Formyl-3-fluoropyridine; 3-Fluoro-2-pyridinecarbothialdehyde; 3-Fluoro-2-thioformylpyridine; 3-Fluoro-2-pyridinethial; 3-Fluoropyridine-2-carbothialdehyde; 2-Thioformyl-3-fluoropyridine; 3-Fluoro-2-thiopyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 3-Fluoropyridine-2-Thialdehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing the results against agreed specifications. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to brown solid or liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.