Description

9-o-Methanoprostaglandin I is a synthetic prostaglandin analog, a member of the prostanoid class of bioactive lipids. This compound is valued for its potent biological activity and serves as a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly those focused on cardiovascular, renal, and inflammatory pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents targeting prostaglandin receptors.
• Biochemical Research: Used as a reference standard in studies investigating prostanoid signaling, receptor binding affinity, and enzyme inhibition (e.g., thromboxane synthase).
• Cardiovascular Research: Employed in preclinical models to study vasodilation, platelet aggregation inhibition, and vascular homeostasis.
• Analytical Standard: Provides a high-purity benchmark for quality control and method validation in HPLC, LC-MS, and other analytical techniques.
• Drug Discovery & Development: Facilitates structure-activity relationship (SAR) studies for designing new molecules with optimized potency and selectivity.

Basic Information

Product Name	9-o-Methanoprostaglandin I
CAS No.	99946-24-4
Molecular Formula	C₂₁H₃₄O₅
Molecular Weight	366.5 g/mol
Synonyms	9-O-Methano-PGI; 9-o-Methano-PGI2; 9-o-Methanoprostacyclin; 9-O-Methano-prostaglandin I2; (5Z,9α,11α,13E,15S)-9,11-Epoxy-15-hydroxyprosta-5,13-dien-1-oic Acid, 9-O-Methano Derivative; Prostaglandin I2, 9-O-methano-; 9-O-Methanoprostaglandin I₂
EINECS	Contact for details

Quality Control

Our 9-o-Methanoprostaglandin I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high purity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.