Description

Pyroglutamyl-Histidyl-Proline Thioamide is a synthetic peptide derivative, specifically a thioamide analog of the tripeptide TRH (Thyrotropin-Releasing Hormone). This compound is of significant interest in advanced pharmaceutical research and development due to its modified peptide backbone, which can alter biological activity, stability, and receptor binding profiles compared to its oxo-amide counterpart. It serves as a critical building block and reference standard for researchers in neuroendocrinology, peptide chemistry, and drug discovery, enabling the study of structure-activity relationships and the development of novel therapeutic agents.

Application

• Pharmaceutical R&D: Used as a key intermediate or reference standard in the development of novel peptide-based therapeutics and diagnostic agents.
• Neuroscience Research: Serves as a tool compound for studying the TRH receptor pathway, neuroendocrine regulation, and potential neurological disorders.
• Peptide Chemistry Studies: Employed in academic and industrial research to investigate the effects of thioamide substitution on peptide conformation, stability, and biological activity.
• Bioconjugation & Probe Development: Acts as a precursor for creating labeled probes (e.g., fluorescent, radioactive) for imaging and biochemical assays.
• High-Purity Reference Material: Provides a certified standard for quality control and analytical method development in peptide manufacturing.

Basic Information

Product Name	Pyroglutamyl-Histidyl-Proline Thioamide
CAS No.	99933-27-4
Molecular Formula	C16H22N6O3S
Molecular Weight	378.45 g/mol
Synonyms	pGlu-His-Pro-NH-thio; TRH Thioamide; Thyrotropin-Releasing Hormone Thioamide; L-Pyroglutamyl-L-histidyl-L-prolinethioamide; 5-Oxo-L-prolyl-L-histidyl-L-prolinethioamide; (S)-1-((S)-6-(2-((S)-5-Oxopyrrolidine-2-carboxamido)ethyl)-1H-imidazol-4-yl)-2-(thioxohexahydropyrrolo[1,2-a]pyrazin-4(1H,6H,7H,7aH)-yl)ethan-1-one
EINECS	Contact for details

Quality Control

Our Pyroglutamyl-Histidyl-Proline Thioamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity checks, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We can support development projects with custom purity grades and analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.