Description

H-Pro-Leu-Gly-NH2 is a synthetic tripeptide amide derivative of the C-terminal sequence of the thyrotropin-releasing hormone (TRH). This compound is of significant interest in biochemical and pharmaceutical research due to its role as a key intermediate and a model peptide for studying neuropeptide structure-activity relationships. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, neuroendocrinology studies, and the development of novel therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Research Intermediate: Serves as a critical building block in the synthesis of more complex peptide analogs and potential drug candidates.
• Neuroscience Studies: Used as a reference compound in research investigating the metabolism, stability, and biological activity of thyrotropin-releasing hormone (TRH) and related peptides.
• Biochemical Tool: Employed in enzymatic studies to understand peptidase specificity and the degradation pathways of neuropeptides.
• Peptide Library Construction: A valuable component in the generation of combinatorial peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial R&D: Fundamental research material in university and corporate laboratories focusing on peptide chemistry and neuroendocrinology.

Basic Information

Product Name	H-Pro-Leu-Gly-NH2
CAS No.	2002-44-0
Molecular Formula	C14H24N4O4
Molecular Weight	312.36 g/mol
Synonyms	L-Pyroglutamyl-L-leucylglycinamide; Pyroglutamyl-Leucyl-Glycinamide; pGlu-Leu-Gly-NH2; TRH-(2-4); Thyrotropin-Releasing Hormone Fragment (2-4); Pro-Leu-Gly Amide; (S)-1-((S)-2-((S)-5-Oxo-2-pyrrolidinecarboxamido)-4-methylpentanamido)-2-aminoethanone
EINECS	Contact for details

Quality Control

Our H-Pro-Leu-Gly-NH2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, chiral analysis to confirm stereochemical integrity, and identity confirmation via mass spectrometry (MS) and infrared spectroscopy (IR). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.