Description

Exendin-4 is a synthetic 39-amino acid peptide and a potent, long-acting agonist of the glucagon-like peptide-1 (GLP-1) receptor. This compound is of significant commercial and research interest due to its role as the active pharmaceutical ingredient in exenatide, a medication used for the treatment of type 2 diabetes. It is primarily utilized by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in metabolic disease research and drug development.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of exenatide-based injectable therapies for glycemic control in type 2 diabetes.
• Biomedical Research: Critical tool for in vitro and in vivo studies investigating GLP-1 receptor signaling, insulin secretion, and β-cell function.
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of next-generation GLP-1 receptor agonists and combination therapies.
• Preclinical Studies: Employed in animal models to study pharmacokinetics, efficacy, and safety profiles of anti-diabetic treatments.
• Diagnostic Reagent Manufacturing: Serves as a key component in the production of assay kits and reagents for diabetes-related biomarker analysis.

Basic Information

Product Name	Exendin-4
CAS No.	141758-74-9
Molecular Formula	C184H282N50O60S
Molecular Weight	4186.6 g/mol
Synonyms	Exenatide; AC 2993; LY2148568; Synthetic Exendin-4; Lizard Venom Peptide; GLP-1 Receptor Agonist; [Ser39]Exendin-4 (39 aa); H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
EINECS	Contact for details

Quality Control

Our Exendin-4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, aligning with ICH guidelines for peptide APIs. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for HPLC purity, peptide content, amino acid analysis, and endotoxin levels.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.