Description

Melittin is a potent, amphipathic polypeptide and the primary active component of honey bee (*Apis mellifera*) venom. This compound matters for its significant lytic activity against cell membranes, making it a critical tool for biophysical research and a model for studying peptide-membrane interactions. Industries and researchers in pharmaceuticals, biotechnology, and life sciences need it for applications ranging from antimicrobial agent development to cancer research and the study of cellular mechanisms.

Application

• Biomedical Research: As a model peptide for studying membrane permeabilization, pore formation, and cell lysis mechanisms.
• Antimicrobial Studies: Investigation of its potent antibacterial, antifungal, and antiviral properties for potential therapeutic development.
• Cancer Research: Exploration of its cytotoxic effects on various cancer cell lines and its potential in targeted drug delivery systems.
• Neuroscience: Study of its effects on neuronal cells and pain pathways, given its role in bee venom's inflammatory response.
• Biophysical Analysis: Used in experiments to understand lipid bilayer dynamics, peptide folding, and protein-lipid interactions.
• Drug Discovery: Serves as a lead compound or a structural template for designing novel peptide-based therapeutics.
• Toxinology: Essential for research into venom composition, toxicity mechanisms, and antivenom development.
• Diagnostic Reagent Development: Potential use in assays requiring controlled cell membrane disruption.

Basic Information

Product Name	Melittin
CAS No.	20449-79-0
Molecular Formula	C₁₃₁H₂₂₉N₃₉O₃₁
Molecular Weight	2846.46 g/mol
Synonyms	Apitoxin; Bee Venom Peptide; Melittin I; Apidacec; Melitten; NSC 106977; Honey Bee Venom Basic Peptide; 26-L-Melittin; H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
EINECS	243-831-2

Quality Control

Our Melittin is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to relevant industry standards for peptide synthesis and purification to meet the exacting requirements of the global scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Amino Acid Analysis)	≥ 97%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Hemolytic Activity	Confirmed (Contact for details)
Endotoxin Level	< 100 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.