Description

Nesiritide Acetate is a synthetic 32-amino acid polypeptide and the acetate salt form of human B-type natriuretic peptide (hBNP). This compound is a critical active pharmaceutical ingredient (API) with significant therapeutic value. It is primarily required by pharmaceutical manufacturers and research institutions for the formulation of treatments for acute decompensated heart failure.

Application

• Pharmaceutical API: Primary use as the active ingredient in parenteral formulations for the treatment of acutely decompensated congestive heart failure.
• Clinical Research: Used as a reference standard and investigational agent in cardiovascular research and clinical trials.
• Biochemical Research: Serves as a key reagent in studies of natriuretic peptide pathways, vasodilation, and renal function.
• Diagnostic Development: Potential use in the calibration and development of diagnostic assays for BNP and related biomarkers.

Basic Information

Product Name	Nesiritide Acetate
CAS No.	114471-18-0
Molecular Formula	C143H244N50O42S4 • xC2H4O2
Molecular Weight	Approx. 3464 g/mol (free base)
Synonyms	Human B-type Natriuretic Peptide (hBNP) Acetate; Natrecor® (Brand Name); BNP-32 Acetate; Nesiritide; Recombinant Human BNP; Carperitide Acetate (related analog); SC-465471
EINECS	Contact for details

Quality Control

Our Nesiritide Acetate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for HPLC purity, peptide content, acetic acid content, residual solvents, and bioburden.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the label. Due to its hygroscopic nature, the product should be stored in a dry environment. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Assay (HPLC)	≥ 98.0%
Peptide Content	≥ 80.0% (by weight)
Acetic Acid Content	5.0% - 12.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Bacterial Endotoxins	< 10 EU/mg
Bioburden	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.