Description

(D-Ala2)-Leu-Enkephalin CAS NO 64963-01-5 is a synthetic pentapeptide analog of the endogenous opioid peptide Leu-Enkephalin, modified with a D-alanine residue at the second position. This modification enhances its metabolic stability and receptor selectivity, making it a critical tool for neurobiological and pharmacological research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on studying opioid receptor function, pain pathways, and peptide biochemistry.

Application

• Neuroscience Research: As a selective ligand for studying delta (δ) opioid receptor binding, activation, and signaling pathways in vitro and in vivo.
• Pharmacological Assay Development: Used as a reference standard or active control in high-throughput screening (HTS) assays for novel analgesic drug discovery.
• Biochemical Studies: Investigation of peptide stability, enzyme degradation kinetics (e.g., by peptidases), and structure-activity relationships (SAR) of opioid peptides.
• Diagnostic Reagent Component: Potential use in the development of diagnostic kits or assays for research into endogenous opioid systems.
• Academic & Educational Use: Serves as a teaching tool in advanced university courses for biochemistry, neuropharmacology, and medicinal chemistry.

Basic Information

Product Name	(D-Ala2)-Leu-Enkephalin
CAS No.	64963-01-5
Molecular Formula	C28H37N5O7
Molecular Weight	555.63 g/mol
Synonyms	DADLE; [D-Ala2]-Leu-Enkephalin; [D-Ala2]-Leu-Enkephalin Acetate; Tyr-D-Ala-Gly-Phe-Leu; H-Tyr-D-Ala-Gly-Phe-Leu-OH; (D-Alanine2)-Leucine-Enkephalin; Delta opioid receptor agonist DADLE; [D-Ala2, Leu5]-Enkephalin
EINECS	Contact for details

Quality Control

Our (D-Ala2)-Leu-Enkephalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.