Description

Orexin A (17-33) is a bioactive peptide fragment derived from the full-length Orexin A neuropeptide, identified by CAS No. 343268-91-7. This compound is a critical research tool for investigating the orexinergic system, which plays a pivotal role in regulating sleep-wake cycles, arousal, appetite, and energy homeostasis. It is essential for neuroscientists, pharmacologists, and biochemists engaged in neuroscience research, drug discovery, and metabolic studies, providing a specific ligand for probing OX1 receptor interactions and signaling pathways.

Application

• Neuroscience Research: Used as a selective agonist for studying the structure and function of orexin receptors (OX1) in the central nervous system.
• Sleep/Wake Disorder Studies: A key reagent in preclinical research models investigating narcolepsy, insomnia, and other arousal-related disorders.
• Pharmacological Assay Development: Serves as a reference standard in competitive binding assays and functional cellular assays to screen for novel orexin receptor modulators.
• Metabolic and Appetite Regulation Research: Employed in studies exploring the link between the orexin system, feeding behavior, and energy expenditure.
• Academic and Institutional R&D: Fundamental tool for university and pharmaceutical R&D departments focusing on neuropeptide signaling and G-protein coupled receptor (GPCR) biology.
• Biochemical Reagent: Used in the preparation of samples for analytical techniques such as mass spectrometry and immunoassays.

Basic Information

Product Name	Orexin A (17-33)
CAS No.	343268-91-7
Molecular Formula	C78H122N24O22S2
Molecular Weight	1764.1 g/mol
Synonyms	Hypocretin-1 (17-33); Orexin-A (17-33); OXA (17-33); Pyr-Gly-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-NH2 (disulfide bridge: Cys7-Cys14 and Cys8-Cys15); Hcrt1 (17-33); Neuropeptide Orexin A fragment 17-33
EINECS	Contact for details

Quality Control

Our Orexin A (17-33) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.