Description

α-Msh (11-13) (Free Acid) is a specific peptide fragment derived from the α-Melanocyte-Stimulating Hormone (α-MSH) sequence. This compound is of significant interest in biochemical and pharmacological research due to its role in studying melanocortin receptor interactions and signaling pathways. It is primarily utilized by researchers and developers in the fields of pharmaceutical R&D, peptide synthesis, and life science research for investigating skin pigmentation, inflammation, and appetite regulation mechanisms.

Application

• Biochemical Research: Used as a reference standard and tool compound for studying melanocortin receptors (MC1R, MC3R, MC4R, MC5R).
• Pharmaceutical Development: Serves as a key intermediate or active pharmacophore in the development of novel therapeutics targeting metabolic disorders or inflammatory conditions.
• Peptide Chemistry: Employed in solid-phase peptide synthesis (SPPS) for constructing larger, more complex α-MSH analogs or conjugates.
• Cell Signaling Studies: Applied in in vitro assays to investigate intracellular cAMP production and downstream signaling cascades.
• Cosmeceutical Research: Investigated for potential applications in modulating skin pigmentation and responses to UV radiation.

Basic Information

Product Name	α-Msh (11-13) (Free Acid)
CAS No.	67727-97-3
Molecular Formula	C20H32N6O6
Molecular Weight	452.5 g/mol
Synonyms	α-MSH (11-13); H-Lys-Pro-Val-NH2 (Free Acid); α-Melanocyte Stimulating Hormone (11-13); Melanotropin (11-13); L-Lysyl-L-prolyl-L-valinamide; Acetyl-α-MSH (11-13) core sequence; KPV peptide (Free Acid form)
EINECS	Contact for details

Quality Control

Our α-Msh (11-13) (Free Acid) is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques, including HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and compliance with specified standards. We support research and development with material suitable for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.