Description

Droxinostat CAS NO 99873-43-5 is a potent and selective small molecule inhibitor of histone deacetylase (HDAC) enzymes, specifically targeting Class I HDACs. This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and apoptosis in various disease models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurology, and metabolic disorder research.

Application

• Biomedical Research: A key reagent for studying the role of HDAC inhibition in cancer cell proliferation, differentiation, and programmed cell death.
• Epigenetics Studies: Used to modulate chromatin structure and gene expression patterns in cellular and animal models to understand epigenetic mechanisms.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the screening and development of novel HDAC-targeted therapeutics.
• Neurological Research: Investigated for its potential neuroprotective effects and role in models of neurodegenerative diseases.
• Biochemical Assays: Employed in in vitro enzymatic assays to determine HDAC activity and inhibitor potency.

Basic Information

Product Name	Droxinostat
CAS No.	99873-43-5
Molecular Formula	C₁₉H₂₀N₄O₄
Molecular Weight	368.39 g/mol
Synonyms	N-Hydroxy-4-[[(2S)-2-(1H-indol-3-ylmethyl)-1-methyl-2-pyrrolidinyl]methyl]benzamide; PCI-24781; CRA-024781; (S)-N-Hydroxy-4-((1-methyl-2-(1H-indol-3-ylmethyl)pyrrolidin-2-yl)methyl)benzamide; HDAC Inhibitor IX; Abexinostat
EINECS	Contact for details

Quality Control

Our Droxinostat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.