Description

4-(3-Butyl-Ureido)-Benzenesulfonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in advanced organic synthesis. Its molecular structure, featuring both a sulfonyl chloride group and a urea moiety, makes it a versatile building block for constructing complex molecules with specific functionalities. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel sulfonamides and other active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting enzymes where sulfonamide groups are key pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactivity to introduce sulfonylurea-like structures.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors due to the electrophilic sulfonyl chloride group.
• Material Science Research: Employed in the creation of functionalized polymers and advanced materials where the introduction of sulfonamide linkages is required.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	4-(3-Butyl-Ureido)-Benzenesulfonyl Chloride
CAS No.	99857-81-5
Molecular Formula	C₁₁H₁₅ClN₂O₃S
Molecular Weight	290.77 g/mol
Synonyms	1-Butyl-3-(4-(chlorosulfonyl)phenyl)urea; N-Butyl-N'-(4-chlorosulfonylphenyl)urea; 4-(N'-Butylureido)benzenesulfonyl chloride; p-(3-Butylureido)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-[(butylamino)carbonyl]amino]-; Urea, N-butyl-N'-[4-(chlorosulfonyl)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of 4-(3-Butyl-Ureido)-Benzenesulfonyl Chloride is produced and tested under stringent quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity (by IR and NMR), and impurity profiles. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.