Description

Acitretin o-β-D-Glucuronide is a major, pharmacologically active metabolite of the retinoid drug acitretin. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a vital reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring high-purity materials for analytical and regulatory purposes.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative and qualitative analysis in drug development.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo studies to map the metabolic pathways of Acitretin.
• Bioanalytical Method Development: Used as a calibration standard in HPLC, LC-MS, and LC-MS/MS assays for pharmacokinetic (PK) studies.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to verify the identity and purity of Acitretin and related substances.
• Regulatory Submissions: Supports the preparation of documentation for regulatory agencies (e.g., FDA, EMA) by providing definitive metabolite characterization data.
• Academic & Clinical Research: Facilitates research into retinoid pharmacology, dermatology treatments, and metabolic disorders.

Basic Information

Product Name	Acitretin o-β-D-Glucuronide
CAS No.	99792-36-6
Molecular Formula	C29H38O9
Molecular Weight	530.61 g/mol
Synonyms	Acitretin Glucuronide; Acitretin β-D-Glucuronide; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid β-D-Glucopyranosiduronic acid; Ro 10-1670 Glucuronide; Etretin Glucuronide; Neotigason Metabolite
EINECS	Contact for details

Quality Control

Our Acitretin o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific results and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.