Description

α-Helical Crf (9-41) is a synthetic peptide fragment of corticotropin-releasing factor (CRF), a key neurohormone involved in the stress response. This specific sequence is designed to adopt an α-helical conformation, making it a critical tool for studying receptor-ligand interactions and signal transduction pathways in neuroendocrine research. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on neuroscience, stress-related disorders, and peptide-based drug discovery.

Application

• Neuroscientific Research: Used as a reference standard or active agent in studies investigating the CRF system, stress physiology, and anxiety disorders.
• Receptor Binding Assays: Serves as a high-affinity ligand for characterizing CRF receptor subtypes (CRF1 and CRF2) and screening for receptor antagonists.
• Biochemical Tool: Employed in structure-activity relationship (SAR) studies to understand the role of the α-helical domain in CRF bioactivity.
• Pharmaceutical Development: Acts as a key intermediate or reference compound in the R&D pipeline for novel neuropeptide therapeutics.
• Cell Signaling Studies: Utilized to stimulate or inhibit CRF-mediated pathways in in vitro cell culture models to study downstream effects.

Basic Information

Product Name	α-Helical Crf (9-41)
CAS No.	99658-03-4
Molecular Formula	C178H294N56O48S
Molecular Weight	4019.7 g/mol
Synonyms	α-Helical CRF (9-41); α-Helical Corticotropin-Releasing Factor (9-41); CRF (9-41), α-helical; h/rCRF(9-41); Cyclo(30-33)[Ac-Pro30, D-Phe32, Nle33]h/rCRF(9-41); Corticoliberin (9-41) fragment, α-helical; Astressin analog; CRF receptor antagonist peptide
EINECS	Contact for details

Quality Control

Every batch of α-Helical Crf (9-41) is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and peptide content are provided with each shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.