Description

K-252B is a potent and selective indolocarbazole alkaloid derivative, valued for its significant biological activity as a protein kinase inhibitor. This compound is crucial for advanced biochemical research and pharmaceutical development, particularly in studying cellular signaling pathways. It is primarily utilized by researchers and manufacturers in the life sciences sector for drug discovery, neuroscience studies, and cancer research.

Application

• Biochemical Research: Used as a selective inhibitor of protein kinase C (PKC) and other serine/threonine kinases in mechanistic studies.
• Pharmaceutical Development: Serves as a key reference standard and intermediate in the discovery and synthesis of novel therapeutic agents.
• Neuroscience Studies: Employed in research models to investigate neurotrophic signaling, neuronal survival, and differentiation.
• Oncology Research: Applied in vitro and in vivo to study apoptosis and cell cycle regulation in various cancer cell lines.
• Enzyme Profiling: A valuable tool for high-throughput screening and profiling the selectivity of kinase inhibitor libraries.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology and signal transduction.

Basic Information

Product Name	K-252B
CAS No.	99570-78-2
Molecular Formula	C₂₇H₂₁N₃O₅
Molecular Weight	467.47 g/mol
Synonyms	9-Hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8H-8,13b-epoxy[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-5(7H)-one; K252b; KT 5720 analog; Staurosporine analog; CEP 1347 analog; Indolocarbazole K-252B; Protein kinase inhibitor K-252B
EINECS	Contact for details

Quality Control

Our K-252B is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.