Description

K-252A is a potent and selective cell-permeable inhibitor of protein kinase C (PKC) and other serine/threonine kinases, widely recognized for its high biological activity in biochemical research. This compound is a critical tool for studying intracellular signal transduction pathways, cellular proliferation, and apoptosis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery and advanced biochemical studies.

Application

• Biochemical Research: A key reagent for investigating the role of protein kinase C and related kinases in cellular signaling cascades.
• Pharmaceutical R&D: Used as a reference standard and pharmacological tool in the discovery and development of novel kinase-targeted therapeutics.
• Neuroscience Studies: Applied in research models to study neuroprotection, neuronal differentiation, and the mechanisms of neurodegenerative diseases.
• Cell Biology: Employed to modulate kinase activity in cell culture experiments to study effects on growth, differentiation, and programmed cell death (apoptosis).
• Enzyme Inhibition Assays: Serves as a potent inhibitor in high-throughput screening (HTS) and in vitro kinase activity assays.

Basic Information

Product Name	K-252A
CAS No.	99533-80-9
Molecular Formula	C₂₇H₂₁N₃O₅
Molecular Weight	467.47 g/mol
Synonyms	K252a; CEP-701; (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester; Staurosporine analog; Protein kinase C inhibitor K-252a; KT-252A; Antibiotic K 252a
EINECS	Contact for details

Quality Control

Our K-252A is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.