Description

9,10-Dimethylmethano-11,12-Methano-16-(4-Methoxyphenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2 is a sophisticated synthetic analog of thromboxane A2, a key bioactive lipid mediator. This compound is of significant value for pharmaceutical research and development, particularly in the study of cardiovascular and thrombotic pathways. It serves as a critical reference standard and a key intermediate for researchers and manufacturers in the life sciences sector, enabling the development of novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and the validation of bioanalytical methods in drug development.
• Biochemical Research: Acts as a potent tool compound for studying thromboxane receptor (TP receptor) signaling, platelet aggregation mechanisms, and vascular biology.
• Drug Discovery Intermediate: Serves as a key synthetic building block for the preparation of novel thromboxane synthase inhibitors or receptor antagonists targeting cardiovascular diseases.
• Academic Research: Utilized in university and institutional labs for fundamental research into eicosanoid metabolism and the role of thromboxane in inflammation and hemostasis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of advanced active pharmaceutical ingredients (APIs).

Basic Information

Product Name	9,10-Dimethylmethano-11,12-Methano-16-(4-Methoxyphenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2
CAS No.	99473-03-7
Molecular Formula	C24H31NO4
Molecular Weight	397.51 g/mol
Synonyms	13-Aza-15-tetranor-thromboxane A2 analog; 16-(4-Methoxyphenyl)-13,14-dihydro-13-aza-15-tetranor-TXA2; 9,10-Dimethylmethano-11,12-methano-16-(p-methoxyphenyl)-13,14-dihydro-13-aza-15-tetranorthromboxane A2; Thromboxane A2 mimetic; TP receptor ligand; SQ 28,668 (related analog series); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 9,10-Dimethylmethano-11,12-Methano-16-(4-Methoxyphenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support research and regulatory requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our quality commitment ensures material suitable for use as a pharmaceutical reference standard and in cGMP intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a dry environment to minimize moisture absorption. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.