Description

N(Alpha)-Tosylglycyl-4-Amidinophenylalanine Piperidide is a synthetic, peptidomimetic compound designed as a potent and selective inhibitor of serine proteases. Its value lies in its high specificity, making it an essential research tool for studying enzymatic pathways and developing therapeutic agents. This compound is primarily needed by pharmaceutical R&D teams, biochemical researchers, and diagnostic manufacturers focused on coagulation, inflammation, and oncology-related protease targets.

Application

• Biochemical Research: A critical tool for studying the mechanism and inhibition of specific serine proteases like trypsin, thrombin, and related enzymes.
• Pharmaceutical Development: Serves as a lead compound or reference standard in drug discovery programs targeting thrombotic disorders, inflammatory diseases, and certain cancers.
• Diagnostic Reagent Formulation: Used in the development of in vitro diagnostic kits to modulate or calibrate protease activity in clinical samples.
• Enzyme Characterization: Employed to determine kinetic parameters (Ki, IC50) and elucidate the structure-activity relationships (SAR) of protease active sites.
• Cell Biology Studies: Applied in cellular assays to inhibit specific proteolytic activity and study its role in signal transduction and cellular processes.

Basic Information

Product Name	N(Alpha)-Tosylglycyl-4-Amidinophenylalanine Piperidide
CAS No.	99452-52-5
Molecular Formula	C26H34N6O5S
Molecular Weight	542.65 g/mol
Synonyms	4-Amidinophenylalanine Piperidide Tosylglycyl Ester; TAPI-1; TAPI 1; TAPI1; Tosylglycyl-4-Amidinophenylalanine Piperidide; N(α)-Tosylglycyl-4-Amidinophenylalanine Piperidide; TNF-α Protease Inhibitor-1; TNF-alpha Converting Enzyme Inhibitor
EINECS	Contact for details

Quality Control

Every batch of N(Alpha)-Tosylglycyl-4-Amidinophenylalanine Piperidide is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to minimize condensation and exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.