Description

Metaphit Methanesulfonate is a specialized research chemical and a potent, irreversible antagonist for the phencyclidine (PCP) binding site of the NMDA receptor complex. Its high specificity makes it a critical tool for neuropharmacological research, enabling the study of glutamate receptor function and excitotoxicity. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, neurodegenerative disease models, and anesthetic mechanisms.

Application

• Neuroscience Research: A key pharmacological tool for studying the N-methyl-D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels.
• Neuropharmacology: Used to irreversibly block the PCP site, facilitating research into excitatory synaptic transmission, synaptic plasticity, and long-term potentiation (LTP).
• Disease Model Studies: Employed in preclinical research to model conditions related to NMDA receptor dysfunction, such as stroke, epilepsy, and neurodegenerative diseases.
• Anesthetic Mechanism Research: Investigates the role of NMDA receptors in the action of dissociative anesthetics like ketamine and phencyclidine.
• Biochemical Assay Development: Serves as a reference standard and ligand in receptor binding assays and other in vitro test systems.

Basic Information

Product Name	Metaphit Methanesulfonate
CAS No.	99287-12-4
Molecular Formula	C11H16ClN2O3S
Molecular Weight	291.78 g/mol
Synonyms	1-[1-(3-Isothiocyanatophenyl)cyclohexyl]piperidine Methanesulfonate; Metaphit; PCPA; Phencyclidine Isothiocyanate Analog; NMDA Receptor Antagonist; PCP Site Irreversible Antagonist
EINECS	Contact for details

Quality Control

Our Metaphit Methanesulfonate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.