Description

(2-Hydroxypropyl)-α-Cyclodextrin is a chemically modified derivative of α-cyclodextrin, designed to enhance solubility and complexation capabilities. This modification is critical for improving the bioavailability and stability of poorly soluble active ingredients in various formulations. It serves as a key functional excipient for pharmaceutical researchers, nutraceutical developers, and specialty chemical manufacturers seeking advanced delivery solutions.

Application

• Pharmaceutical Solubilization & Stabilization: Enhances the aqueous solubility, dissolution rate, and chemical stability of poorly soluble APIs (Active Pharmaceutical Ingredients) in oral, topical, and parenteral formulations.
• Drug Delivery Systems: Acts as a functional carrier in the development of controlled-release systems, nanoparticles, and inclusion complexes to improve drug targeting and efficacy.
• Analytical Chemistry & Research: Used as a chiral selector in capillary electrophoresis and HPLC for enantiomeric separation and analysis.
• Nutraceutical & Cosmetic Formulations: Improves the stability, solubility, and bioavailability of sensitive bioactive compounds, flavors, and fragrances.
• Chemical Synthesis & Catalysis: Serves as a supramolecular host in aqueous reaction media to influence reaction rates and selectivity.

Basic Information

Product Name	(2-Hydroxypropyl)-α-Cyclodextrin
CAS No.	99241-24-4
Molecular Formula	C42H70O35 · (C3H6O)n
Molecular Weight	~972-1540 g/mol (variable, depends on degree of substitution)
Synonyms	HP-α-CD; Hydroxypropyl-α-Cyclodextrin; 2-HP-α-CD; α-Hydroxypropylcyclodextrin; (2-Hydroxypropyl)-α-Cyclodextrin; Heptakis(2-hydroxypropyl)-α-cyclodextrin; α-Cyclodextrin, 2-hydroxypropyl ether; Hydroxypropyl alpha Cyclodextrin
EINECS	Contact for details

Quality Control

Our (2-Hydroxypropyl)-α-Cyclodextrin is manufactured under a quality management system. Each batch is tested to ensure it meets stringent specifications for identity, purity, and substitution degree. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support compliance with cGMP and relevant ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed to prevent absorption of atmospheric moisture, which can affect product performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-α-CD, HPLC)	≥ 98.0%
Degree of Substitution (MS)	0.6 - 1.0 (or as specified)
Water Content (KF)	≤ 10.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Microbial Enumeration	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.