Description

β-Cyclodextrin Tetradecasulfate is a highly sulfated derivative of β-cyclodextrin, characterized by its strong anionic charge and enhanced water solubility. This compound is valued for its superior ability to form inclusion complexes with a wide range of guest molecules, particularly cationic and hydrophobic species, making it a powerful tool for solubility enhancement and controlled release. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors for applications in drug delivery, enzyme inhibition, and as a chiral selector in separation science.

Application

• Pharmaceutical Research & Drug Delivery: Acts as a complexing agent to improve the solubility, stability, and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
• Enzyme Inhibition Studies: Used as a potent inhibitor for studying heparin-binding proteins and enzymes like basic fibroblast growth factor (bFGF) due to its structural mimicry of heparin.
• Chiral Separation Media: Serves as a chiral selector in capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) for the separation of enantiomers.
• Biomaterial & Hydrogel Formulation: Incorporated into hydrogels and scaffolds for tissue engineering, leveraging its ionic character and biocompatibility.
• Analytical Chemistry Reagent: Employed as a specialized reagent for protein binding studies and the analysis of polycationic compounds.
• Catalyst & Reaction Modifier: Utilized in chemical synthesis to modify reaction pathways and enhance selectivity through host-guest chemistry.

Basic Information

Product Name	β-Cyclodextrin Tetradecasulfate
CAS No.	121369-51-5
Molecular Formula	C42H70O112S14 (Approximate)
Molecular Weight	~ 3000 g/mol (Approximate)
Synonyms	β-Cyclodextrin Tetradecasulfate; β-CD-14-Sulfate; Heptakis(2,3,6-tri-O-sulfo)-β-cyclodextrin; Sulfated β-Cyclodextrin (High Degree of Substitution); β-Cyclodextrin Polysulfate; Cyclodextrin Sulfate Salt; 14-Sulfo-β-cyclodextrin; Heparin Mimic Cyclodextrin
EINECS	Contact for details

Quality Control

Our β-Cyclodextrin Tetradecasulfate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure consistency and meets high-purity standards suitable for research and development. Certificates of Analysis (COA) detailing key parameters such as degree of substitution (DS), purity, and impurity profile are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Degree of Substitution (DS)	~ 14 (by elemental analysis)
Water Content (KF)	≤ 5.0 %
Residue on Ignition (Sulfated Ash)	25.0 - 35.0 %
Heavy Metals (as Pb)	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.