Description

Hexakis-(2,3-Di-o-Acetyl-6-o-Tert.-Butyldimethylsilyl)-α-Cyclodextrin is a highly functionalized, chemically modified derivative of α-cyclodextrin, designed for advanced molecular encapsulation and chiral separation applications. This compound matters for its enhanced solubility in organic solvents and its ability to form stable, selective inclusion complexes with a wide range of guest molecules, offering superior performance over native cyclodextrins. It is critically needed by researchers and manufacturers in pharmaceutical development, analytical chemistry, and specialty chemical synthesis for applications such as chiral stationary phases, drug delivery systems, and catalyst modifiers.

Application

• Chiral Chromatography: As a key component in chiral stationary phases (CSPs) for High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) to separate enantiomers of pharmaceutical intermediates and active ingredients.
• Pharmaceutical Research: For studying drug-cyclodextrin inclusion complexes to improve the solubility, stability, and bioavailability of poorly soluble Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: As a chiral auxiliary or host molecule in organic synthesis to induce enantioselectivity in catalytic reactions.
• Analytical Reference Standard: Used as a high-purity standard for method development and validation in analytical laboratories.
• Supramolecular Chemistry: As a building block for constructing sophisticated molecular machines, sensors, and delivery vehicles due to its tailored cavity and functional groups.
• Flavor & Fragrance Encapsulation: For the controlled release and stabilization of sensitive aroma compounds in specialty formulations.

Basic Information

Product Name	Hexakis-(2,3-Di-o-Acetyl-6-o-Tert.-Butyldimethylsilyl)-α-Cyclodextrin
CAS No.	118663-74-4
Molecular Formula	C96H168O36Si6
Molecular Weight	~ 2027.0 g/mol
Synonyms	Peracetylated Per-tert-butyldimethylsilylated α-Cyclodextrin; Hexakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-α-cyclodextrin; α-Cyclodextrin, 2,3-di-O-acetyl-6-O-(1,1-dimethylethyl)dimethylsilyl ether; Fully Acetylated and Silylated α-Cyclodextrin; 2,3-Di-O-acetyl-6-O-tert-butyldimethylsilyl-α-cyclodextrin; TBDMS-Ac-α-CD; Modified α-Cyclodextrin Derivative
EINECS	Contact for details

Quality Control

Our Hexakis-(2,3-Di-o-Acetyl-6-o-Tert.-Butyldimethylsilyl)-α-Cyclodextrin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, degree of substitution, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.