Description

Hydroxypropyl-γ-Cyclodextrin is a chemically modified cyclic oligosaccharide derived from γ-cyclodextrin, featuring hydroxypropyl groups that significantly enhance its water solubility and reduce its nephrotoxicity. This modification makes it an exceptionally versatile and safe solubilizing and stabilizing agent for a wide range of hydrophobic molecules. It is a critical excipient and formulation component for industries requiring advanced molecular encapsulation, including pharmaceuticals, nutraceuticals, and agrochemicals.

Application

• Pharmaceutical Solubilization & Stabilization: Enhances the aqueous solubility, stability, and bioavailability of poorly soluble active pharmaceutical ingredients (APIs) in injectable, oral, and topical formulations.
• Drug Delivery Systems: Serves as a key component in controlled-release systems, nanoparticle formulations, and targeted delivery platforms to improve drug efficacy and safety profiles.
• Cosmetic & Personal Care: Used to solubilize fragrances, vitamins, and other active ingredients in creams, lotions, and serums, improving product stability and skin penetration.
• Food & Flavor Encapsulation: Protects sensitive flavors, colors, and nutrients from oxidation, light, and heat, extending shelf-life and masking undesirable tastes.
• Agrochemical Formulations: Improves the solubility and environmental stability of pesticides and herbicides, enhancing their application efficiency and rainfastness.
• Analytical Chemistry & Research: Employed as a chiral selector in capillary electrophoresis and HPLC columns for enantiomer separation, and as a tool in biochemical research.

Basic Information

Product Name	Hydroxypropyl-γ-Cyclodextrin
CAS No.	116502-52-4
Molecular Formula	C48H80O40 · (C3H6O)n
Molecular Weight	Variable (based on degree of substitution)
Synonyms	HP-γ-CD; 2-Hydroxypropyl-γ-cyclodextrin; γ-Cyclodextrin, 2-hydroxypropyl ether; Hydroxypropyl Gamma Cyclodextrin; (2-Hydroxypropyl)-γ-cyclodextrin; γ-Cyclodextrin, hydroxypropyl derivative; Cavitron™ HPγCD; Kleptose® HPgamma
EINECS	Contact for details

Quality Control

Our Hydroxypropyl-γ-Cyclodextrin is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and compliance with relevant standards for its intended use. We offer grades suitable for pharmaceutical (including potential compliance with USP/NF or EP monographs), food, and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, substitution degree, residual solvents, and microbiological data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed after initial use to prevent absorption of moisture from the atmosphere, which can lead to caking or degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-γ-CD Content)	≥ 98.0% (on dried basis)
Degree of Substitution (Molar)	0.4 - 1.0 (or as specified)
Water Content (KF)	≤ 10.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Microbiological Enumeration	Meets Ph. Eur./USP criteria
pH (10% solution)	5.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.