Description

6'-(4'-Azido-2'-Nitrophenylamino)Hexanoyldeacetylcolchicine is a specialized colchicine derivative, a bifunctional molecule designed for advanced biochemical research and photolabeling applications. Its core value lies in the strategic incorporation of a photoactivatable azido group and a reactive amino linker, enabling precise cross-linking and conjugation studies. This compound is essential for researchers in pharmaceutical development, chemical biology, and proteomics who require high-purity, well-characterized tools for investigating protein interactions, drug-target engagement, and cellular mechanisms.

Application

• Photochemical Cross-linking Agent: Used in photoaffinity labeling studies to covalently bind and identify biological targets of colchicine and related compounds upon UV light activation.
• Bioconjugation & Probe Synthesis: Serves as a key intermediate for synthesizing fluorescent, biotinylated, or other tagged probes for cellular imaging and detection assays.
• Tubulin & Cytoskeleton Research: A critical tool for investigating the binding dynamics and inhibitory mechanisms of colchicine derivatives on tubulin polymerization and microtubule function.
• Mechanistic Pharmacology: Enables detailed studies on drug-receptor interactions, aiding in the elucidation of pathways involved in anti-inflammatory and anti-cancer activities.
• Chemical Biology Library Screening: Incorporated into compound libraries for high-throughput screening to discover novel modulators of cytoskeletal targets.
• Stable Intermediate for API Synthesis: Used in the research and development phase for creating novel therapeutic agents based on the colchicine scaffold.

Basic Information

Product Name	6'-(4'-Azido-2'-Nitrophenylamino)Hexanoyldeacetylcolchicine
CAS No.	98987-40-7
Molecular Formula	C33H36N6O7
Molecular Weight	628.68 g/mol
Synonyms	Deacetylcolchicine 6'-(4-azido-2-nitrophenylamino)hexanoate; N-(6-((7S,12aS)-7-Hydroxy-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-8-yl)oxy)-6-oxohexyl)-4-azido-2-nitroaniline; ANP-Hexanoyl-DAC; 4-Azido-2-nitrophenylaminohexanoyldeacetylcolchicine; Photoactivatable Colchicine Derivative; Colchicine Photoprobe; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 6'-(4'-Azido-2'-Nitrophenylamino)Hexanoyldeacetylcolchicine is manufactured and analyzed under strict quality protocols to ensure identity, purity, and stability for sensitive research applications. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a freezer dedicated for chemicals. This compound is both light-sensitive and hygroscopic. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.