Description

Concanamycin A is a potent and specific macrolide antibiotic that functions as a highly selective inhibitor of vacuolar-type H+-ATPase (V-ATPase). This compound is a critical research tool for studying intracellular pH regulation, vesicular trafficking, and autophagy processes. It is essential for researchers and developers in the fields of cell biology, biochemistry, and pharmacology, particularly for investigating cancer cell metabolism and lysosomal function. Concanamycin A CAS NO 98932-70-8 is supplied to meet the stringent requirements of advanced life science research.

Application

• Biochemical Research: As a specific V-ATPase inhibitor to study ion transport and organelle acidification.
• Cell Biology Studies: For investigating autophagy, lysosomal function, and intracellular vesicle trafficking pathways.
• Cancer Research: To explore the role of pH regulation in tumor cell survival, metastasis, and drug resistance.
• Pharmacology & Drug Discovery: Used in target validation and screening assays for diseases related to V-ATPase dysfunction.
• Microbiology: Research into the mode of action of macrolide antibiotics and bacterial resistance mechanisms.
• Neuroscience: Studying neurotransmitter storage and release in synaptic vesicles, which depends on V-ATPase activity.

Basic Information

Product Name	Concanamycin A
CAS No.	98932-70-8
Molecular Formula	C46H75NO14
Molecular Weight	866.1 g/mol
Synonyms	Concanamycin A; Antibiotic X 4357B; Folimycin; NSC 326450; V-ATPase Inhibitor; 7-O-Malonyl macrolactin A; (3E,5E,7R,8S,9S,11E,13E,15R,16S)-16-[(2S,3S,4R,5S)-5-[(1S)-1,2-Dimethyl-1-(methylamino)propyl]-3,4-dihydroxyoxolan-2-yl]-8-hydroxy-5,7,9,15-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraene-2,6,10,14-tetrone
EINECS	Contact for details

Quality Control

Our Concanamycin A is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.