Description

12-o-(12-n-Dansylaminododecanoyl)Phorbol CAS NO 98897-17-7 is a specialized, fluorescently labeled derivative of phorbol ester, designed for advanced biochemical and pharmacological research. This compound is a critical tool for studying protein kinase C (PKC) activation, translocation, and receptor binding dynamics with high sensitivity. It is primarily utilized by researchers and scientists in academic institutions, pharmaceutical R&D, and biotechnology companies focused on signal transduction, cancer biology, and neuroscience.

Application

• Biochemical Research: As a fluorescent probe for real-time visualization and quantification of PKC activity and localization in cellular assays.
• Drug Discovery: High-throughput screening (HTS) for identifying and characterizing novel PKC inhibitors or activators.
• Cellular Signaling Studies: Investigation of signal transduction pathways involving PKC isoforms in various disease models.
• Neuroscience Research: Studying the role of PKC in neuronal function, synaptic plasticity, and neurodegenerative disorders.
• Cancer Biology: Research into tumor promotion mechanisms and the development of targeted cancer therapies.
• Method Development: Used in developing new fluorescence-based detection methods, including fluorescence polarization (FP) and fluorescence resonance energy transfer (FRET) assays.

Basic Information

Product Name	12-o-(12-n-Dansylaminododecanoyl)Phorbol
CAS No.	98897-17-7
Molecular Formula	C52H68N2O8S
Molecular Weight	881.17 g/mol
Synonyms	12-O-(12-N-Dansylaminododecanoyl)phorbol 13-acetate; Dansyl-PDBu; D-12; Fluorescent Phorbol Ester; 12-O-[12-[(5-Dimethylaminonaphthalene-1-sulfonyl)amino]dodecanoyl]phorbol 13-acetate; N-[12-[(1-Oxo-2,6a,7,10a-tetrahydro-1H,6H,8H,9H-cyclopenta[c]isochromen-6-yl)oxy]dodecanoyl]-N'-(5-dimethylaminonaphthalene-1-sulfonyl)ethylenediamine (IUPAC-style); Phorbol 12,13-didecanoate, dansylamino derivative
EINECS	Contact for details

Quality Control

Every batch of 12-o-(12-n-Dansylaminododecanoyl)Phorbol is produced and analyzed under strict quality protocols to ensure the highest standards of purity and performance for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and fluorescence properties are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is both light-sensitive and hygroscopic. Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Fluorescence Properties	Ex/Em ~335 nm/~518 nm (in methanol)
Solubility	Soluble in DMSO, DMF, ethanol, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.