Description

Dtyr-Pro-Arg-Chloromethylketone CAS NO 98833-79-5 is a specialized tripeptide chloromethyl ketone derivative, functioning as a potent and irreversible active-site-directed inhibitor of serine proteases. This compound is critical for biochemical research and pharmaceutical development, offering precise control over enzymatic activity. It is primarily utilized by researchers in proteomics, drug discovery, and the development of therapeutic agents targeting specific protease pathways.

Application

• Protease Inhibition Studies: Used as a specific, irreversible inhibitor to study the mechanism and function of serine proteases like trypsin, plasmin, and related enzymes.
• Biochemical Research Reagent: Essential in enzymology for kinetic studies, active site mapping, and understanding protease-substrate interactions.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the design and screening of novel protease inhibitor drugs for conditions such as thrombosis, inflammation, and cancer.
• Proteomics & Diagnostic Assays: Employed in the development of selective assays to detect and quantify specific protease activities in complex biological samples.
• Cell Biology & Signal Transduction: Used to selectively block specific protease-mediated pathways in cell culture models to elucidate their role in cellular processes.

Basic Information

Product Name	Dtyr-Pro-Arg-Chloromethylketone
CAS No.	98833-79-5
Molecular Formula	C24H35ClN6O5
Molecular Weight	523.03 g/mol
Synonyms	D-Tyrosyl-L-prolyl-L-arginine chloromethyl ketone; D-Tyr-Pro-Arg-CH2Cl; D-Tyrosine-Proline-Arginine Chloromethyl Ketone; (2S)-1-[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-carbamoylbutanoyl]pyrrolidine-2-carboxylic acid (2R)-2-amino-3-(4-hydroxyphenyl)propyl ketone hydrochloride; Protease Inhibitor (Trypsin-like); TPCK Analogue (Arg-specific); Benzamidine Derivative Inhibitor
EINECS	Contact for details

Quality Control

Our Dtyr-Pro-Arg-Chloromethylketone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.